Welcome to the Pattern-defined Regulatory Island (PRI) Website.

Although one of the most important functions associated with non-coding genomic regions is to serve as sites of transcriptional regulation, systematically locating these sites remains one of the challenges of modern biology. However, the ongoing sequencing of genomes from diverse species has made comparative genomics approaches towards answering these questions possible. We developed the Pattern-defined Regulatory Island (PRI) algorithm to assemble a database of genomic regions where multiple transcription factor binding sites are conserved in order and in spacing across human, mouse, and rat genomes. This website is the search interface facilitating easy access to the PRI database.

Choose one of the two searches by clicking on the corresponding radio buttons:

Please select at least one transcription factor name (click on names while holding down "Ctrl" key) and click "Submit Search". For binding site sequences associated with a given transcription factor name or vice versa, click here to redirect to GeneACT.

Please input one gene name (as defined by NCBI gene, aliases accepted) and click "Submit Search".

Please note:While 7 binding sites or more within a PRI falls within a 99% confidence interval, we have also made PRIs with 5 or more binding sites available through this search tool. Although the false positive rate is expected to be higher, we still expect there to be some valid regions. However, these PRIs should be interpreted with more caution.

Search for PRIs by Input Sequences

Click here

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UCSC custom tracks

Raw Data